Health of children conceived through assisted reproductive technology.

It is currently estimated that 2 to 3% of children born in France were conceived through assisted reproductive technology (ART). Monitoring these children in the short and medium term therefore raises questions, given the specific characteristics of the patients involved (age, infertility) and the medical and technical methods used. Interpreting the results is challenging, as it is difficult to study a single factor in isolation and numerous confounding factors can skew the conclusions. This article analyzes the existing literature on the subject. According to this literature, it appears established that ART is associated with a moderate risk of preterm birth (OR 1.93 to 2.04), low birth weight (OR of 1.40 to 1.77), and neonatal mortality (OR of 1.68 to 2.40) compared to children conceived naturally, although the source of this risk has not been identified (infertility? clinical and biological procedures?). There is also a significant increase in the rate of congenital malformations (OR of 1.35 in singletons), primarily affecting the cardiovascular, urogenital, or musculoskeletal systems, and epigenetic disorders in children conceived through ART compared to the general population. However, even though these rates are higher than in children conceived naturally, the absolute risks remain moderate and reassuring. Long-term data are satisfactory, with height-weight and psychomotor development similar to that of children conceived naturally. It is necessary to continue monitoring these children to gain a clear understanding of their development into adulthood, and particularly their fertility. (R.A.)

Author(s): Patrat C, Epelboin S

Publishing year: 2011

Pages: 282-4

Weekly Epidemiological Bulletin, 2011, n° 23-24, p. 282-4

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