Levodopa induces long-term motor complications in Parkinson's disease (PD). Therapeutic strategies that prevent motor complications are needed. Our aim was to evaluate the impact of recommendations of a French consensus conference published in 2000 on initial PD therapy. We identified 308 PD patients as part of a population-based study performed within the Mutualité Sociale Agricole in five French districts (2007). Neurologists confirmed PD diagnosis. We compared initial therapy in 102 patients treated before 12/31/2000 to that of 206 patients treated afterwards. Initial treatment was in agreement with the recommendations if dopamine agonists were used in patients <60 years (n = 49) and levodopa in patients e70 years (n = 133). Agreement with the recommendations increased after 2000 (66.0%) compared to before (46.3%, p = 0.025). For patients <60 years, agreement increased (64.0% vs 20.2%, p = 0.017) while it remained stable (66.4% vs 70.6%, p = 0.73) in patients e70 years. The publication of recommendations has influenced initial treatment choices for PD in France.
Auteur : Fayard C, Bonaventure A, Benatru I, Roze E, Dumurgier J, Moisan F, Soumare A, Houssinot J, Dupupet JL, Mazurie JL, Balaboi I, Houeto JL, Krim E, Ranoux D, Goldberg M, Imbernon E, Moreau T, Giroud M, Tzourio C, Elbaz A
Parkinsonism and Related Disorders, 2011, vol. 17, n°. 7, p. 543-6