Circumvention of herd immunity during an outbreak of meningococcal disease could be correlated to escape mutation in the porA Gene of Neisseria meningitidis

Publié le 1 Mars 2001
Mis à jour le 11 septembre 2019

Meningococcal strains isolated during an outbreak were shown to belong to the ET-5 complex and to harbor a mutation in the VR2 region of the porA gene. They were less susceptible to the bactericidal effect of normal human serum than was the ET-5 wild-type strain. These results are of concern, as PorA is a potential target in vaccine design.

Auteur : Taha MK, Bichier E, Perrocheau A, Alonso JM
Infection and immunity, 2001, vol. 69, n°. 3, p. 1971-3