Short term association between ozone and mortality: global two stage time series study in 406 locations in 20 countries

Publié le 10 Février 2020
Mis à jour le 12 mars 2020

Objective: to assess short term mortality risks and excess mortality associated with exposure to ozone in several cities worldwide. Design: two stage time series analysis. Setting: 406 cities in 20 countries, with overlapping periods between 1985 and 2015, collected from the database of Multi-City Multi-Country Collaborative Research Network. Population: deaths for all causes or for external causes only registered in each city within the study period. Main outcome measures Daily total mortality (all or non-external causes only). Results: a total of 45 165 171 deaths were analysed in the 406 cities. On average, a 10 µg/m3 increase in ozone during the current and previous day was associated with an overall relative risk of mortality of 1.0018 (95% confidence interval 1.0012 to 1.0024). Some heterogeneity was found across countries, with estimates ranging from greater than 1.0020 in the United Kingdom, South Africa, Estonia, and Canada to less than 1.0008 in Mexico and Spain. Short term excess mortality in association with exposure to ozone higher than maximum background levels (70 µg/m3) was 0.26% (95% confidence interval 0.24% to 0.28%), corresponding to 8203 annual excess deaths (95% confidence interval 3525 to 12 840) across the 406 cities studied. The excess remained at 0.20% (0.18% to 0.22%) when restricting to days above the WHO guideline (100 µg/m3), corresponding to 6262 annual excess deaths (1413 to 11 065). Above more lenient thresholds for air quality standards in Europe, America, and China, excess mortality was 0.14%, 0.09%, and 0.05%, respectively. Conclusions: results suggest that ozone related mortality could be potentially reduced under stricter air quality standards. These findings have relevance for the implementation of efficient clean air interventions and mitigation strategies designed within national and international climate policies.

Auteur : Vicedo-Cabrera Ana M, Sera Francesco, Liu Cong, Armstrong Ben, Milojevic Ai, Guo Yuming, Tong Shilu, Lavigne Eric, Kyselý Jan, Urban Aleš, Orru Hans, Indermitte Ene, Pascal Mathilde, Huber Veronika, Schneider Alexandra, Katsouyanni Klea, Samoli Evangelia, Stafoggia Massimo, Scortichini Matteo, Hashizume Masahiro, Honda Yasushi, Ng Chris Fook Sheng, Hurtado-Diaz Magali, Cruz Julio, Silva Susana, Madureira Joana, Scovronick Noah, Garland Rebecca M, Kim Ho, Tobias Aurelio, Íñiguez Carmen, Forsberg Bertil, Åström Christofer, Ragettli Martina S, Röösli Martin, Guo Yue-Liang Leon, Chen Bing-Yu, Zanobetti Antonella, Schwartz Joel, Bell Michelle L, Kan Haidong, Gasparrini Antonio
BMJ, 2020, vol. 368, n°. 8233, p. 1-10